|
Scientific Program
Venue: University Cultural Centre, 10 Kent Ridge Crescent, Singapore
119260
(map
of venue)
Day 1 - Monday, 4 December 2006 |
Opening Ceremony and Plenary Session
1 |
8:00 am |
Registration of Participants (Foyer 1) |
8:45 am |
Audience to be seated (Hall) |
8:55 am |
Arrival of Guest of Honor (Hall) |
9:00 am |
Welcome Address: R. Manjunatha KINI (Co-Chairman, Organizing
Committee)
Opening Address: Guest of
Honour: Prof. Shih Choon Fong (President, NUS) |
9:30am |
Plenary P1: Proteomics/Biomarkers
Lee
Hartwell (Fred Hutchinson Cancer
Research centre, Seattle, USA)
Molecular
diagnostics will revolutionize medicine
Sponsored by: National University of
Singapore
Chairperson: Hew Choy Leong |
10:30 am |
Exhibition
Viewing Period / Coffee Break (Foyer) |
Day 1 Morning
Sessions |
|
Session A (Hall)
Cancer Biomarkers
Chairperson: Maxey Chung |
Session B (Theatre)
Cryo-Electron
Microscopy
Chairperson: : K.
Swaminathan |
11:30 am |
Speaker H1:
Samir Hanash (Fred Hutchinson Cancer
Research Centre, Seattle, USA)
New
approaches to cancer biomarker discovery |
Speaker T1:
Tim Baker (University of Carlifornia San Diego,
USA)
Three-dimensional
structures of two partitiviruses infecting the fungus Penicillium stoloniferum |
12:00 Noon |
Speaker H2:
Richard
Simpson (Ludwig Inst
Cancer Research, Melbourne,
Australia)
Pharmacoproteomics:
Strategies for identifying new diagnostic and prognostic
markers for colorectal cancer |
Speaker T2:
Cheng
YiFan (University of
California San Francisco, USA)
Cryo-electron
tomography study of clathrin coated vesicles |
12:30-2:30 pm |
Lunch-Break
and Workshops (12:45- 2:15)
LT7A ?GE
Healthcare
Seisuke
Hattori
Proteomic
analyses of signal transduction pathways using
2D DIGE
Anna Sylvan
High
quality screening and characterization applications using
label-free protein interaction analysis
LT7 ?Sigma-Aldrich
Dian Er Chen
Immunoaffinity
Depletion of Twenty Highly Abundant Proteins in Human
Plasma For Biomarker Discovery
Dian Er Chen
A Novel
Silica-Based Immobilized Metal Affinity Chromatography
(IMAC) Technology for the Enrichment of Phosphopeptides
Following Sample Preparation using an Immobilized Trypsin
Spin Column
Open to all participants |
Day 1 Afternoon Sessions |
|
Session A (Hall)
Systems Biology I
Chairperson: Chew Fook Tim |
Session B (Theatre)
Protein Folding
Chairperson: Song Jianxing |
2: 30 pm |
Speaker H3:
Young-Ki Paik (Yonsei University, Korea)
Proteomic
analysis of daumone signaling pathway in Caenorhabditis
elegans |
Speaker T3:
Peter
Wright (The Scripps
Research Institute, USA)
Intrinsically
disordered proteins: function, folding, and
flexibility |
3:00 pm |
Speaker H4:
Bill Jordan (Victoria University of Wellington, New
Zealand)
Proteomics
and metabolic flux. Can expression proteomics be used to
interpret metabolic flow? |
Speaker T4:
Davis Ng (Temasek Life Science Laboratory,
Singapore)
Protein
quality control and ER stress tolerance |
3:30 pm |
Oral presentation O1:
Paul Huang (Massachusetts Institute of
Technology, USA)
Quantitative
phosphoproteomics analysis of EGFRvIII cellular signaling
networks in glioblastoma |
Oral presentation O2:
D.H. Goetz ( University of California San
Francisco, USA)
SARS
coronavirus major protease substrate specificity and
inhibitor development |
3:45 pm |
Poster Session
and Exhibition / Refreshments (Foyer) |
|
State-of-the-Art Lectures (Hall)
Chairperson: Gunaretnam
Rajagopal |
5:00 pm |
Speaker S1:
Michael
Snyder(Yale University,
USA)
Regulatory
networks in eucaryotes
Sponsored by: Institute of Molecular
and Cell Biology
|
5:45 pm |
Speaker S2:
Paul
Tempst (Memorial Sloan-Kettering
Cancer Center, NY, USA)
Tumor-specific
serum peptidome patterns
Sponsored
by: Bioinformatics Institute |
6:30 pm |
Welcome
Reception (Foyer and Court
Yard) |
End of Day 1
top 
Day 2 - Tuesday, 5 December 2006 |
8:30 am |
Plenary P2: Protein Engineering and
Design
Ueli
Aebi (University of Basel,
Switzerland)
From
actin-bundling proteins to coiled coils and, eventually,
peptide nanoparticles
Sponsored by: GE Healthcare
Chairperson: Andr?
M?ez |
9:30 am |
Exhibition
Viewing Period / Coffee Break (Foyer) |
Day 2 Morning
Sessions |
|
Session A (Hall)
Systems Biology II
Chairperson: Sanjay Swarup |
Session B (Theatre)
Structural Biology I
Chairperson: Mok Yu-Keung,
Henry |
10.30 am |
Speaker H5:
Ruedi
Aebersold (Institute for
Molecular Systems Biology, ETH Z?ich,
Switzerland)
Quantitative
proteomics and systems biology |
Speaker T5:
Udo Heinemann (Max Delbrueck Center for Molecular
Medicine, Berlin, Germany)
Structural
studies of the transport protein particle
(TRAPP) |
11.00 am |
Speaker H6:
Ng
Huck Hui (NUS,
Singapore)
Systems biology of stem cells: mapping
transcription regulatory circuirty in embryonic stem cells |
Speaker T6:
Ming Jie Zhang (Hong Kong University of Science and
Technology, Hong Kong)
Organization
of neuronal signaling complexes by multi-domain scaffold
proteins |
11.30 am |
Speaker H7:
Greg Kellog
Tucker (Lilly Systems Biology,
Singapore)
Applying
integrative systems biology to identify genetic
determinants of drug sensitivity in cancer |
Speaker T7:
David
Hsiao (Academia Sinica,
Taipei)
How
winged helix/forkhead proteins using less conserved
residues to regulate diverse DNA sequence |
12:00 noon |
Speaker H8:
Toshiro Ito (Temasek Life Sciences
Laboratory, Singapore)
Transcriptional
cascades in floral organ identity
control |
Speaker T8:
Kunchithapadam
Swaminathan (NUS,
Singapore)
Crystal
structure analysis of PilS, a type IVB pilin from Salmonella typhi
|
12.30-2.30 pm |
Lunch-Break
and Workshops (12:45- 2:15)
LT7A ? AB/MDS
Sciex
Dale H.
Patterson
From
proteomics to protein-based biomarkers: A toolbox of
opportunity
LT7 ?BioRad
Gideon Schreiber
Architecture
and design of protein-protein binding sites using the
proteon?/B> XPR36 protein interaction array
system
Aran Paulus
Actin
deficiency induces Cofilin phosphorylation: Proteome
analysis of HeLa cells after beta-actin gene silencing
Open to all participants |
Day 2 Afternoon
Sessions |
|
Session A (Hall)
Bioinformatics
Chairperson: Tan Tin Wee |
Session B (Theatre)
Protein-Protein Interactions
Chairperson: Low Boon Chuan |
2:30 pm |
Speaker H9:
Ron Appel (Swiss Institute of
Bioinformatics, Geneva, Switzerland)
MS
analysis: Imaging and protein identification
tools |
Speaker T9:
Susan
Taylor ( University of
California San Diego, USA)
PKA
Dynamics: Dynamics of Activation by
cAMP |
3:00 pm |
Speaker H10:
Gunaretnam
Rajagopal (Bioinformatics Institute,
Singapore)
http://www.dbs.nus.edu.sg/proteomicstructbio06/abstracts/h10.pdf |
Speaker T10:
Lee Weontae (Yonsei
University, Korea)
Structure
and Cell Adhesion Signaling of Syndecan
Proteoglycans |
3:30 pm |
Oral presentation O3:
M. Clifton ( University of Sydney,
Australia)
Does
FOG-1 recruit Sin3b to regulate gene expression? |
Oral presentation O4:
Joanna Pawlak (NUS, Singapore)
Denmotoxin:
A three-finger toxin from colubrid snake Boiga
dendrophila (mangrove catsnake) with bird-specific
activity |
3.45 pm |
Poster
Session and Exhibition / Refreshments (Foyer) |
|
State-of-the-Art Lectures
(Hall)
Chairperson: Richard
Simpson |
5:00 pm |
Speaker S3:
Catherine Au (McGill
University, Canada)
Discovery
proteomics of organelles of the secretory pathway
Sponsored
by: Nanyang Technological University |
5:45 pm |
Speaker S4:
John Yates (The Scripps Research Institute, USA)
Driving
biological discovery using mass
spectrometry
Sponsored
by: Thermo/Alpha Analytical |
End of Day 2
Top
Day 3 - Wednesday, 6 December 2006 |
8:30 am |
Plenary P3: Structural Genomics
Ray Stevens (The Scripps Research Institute, USA)
High
throughput technologies in structural biology
Sponsored by: Applied
Biosystems
Chairperson: Wah Chiu |
| 9:30 am |
Exhibition
Viewing Period / Coffee Break (Foyer) |
Day 3
Morning Sessions |
|
Session A (Hall)
Proteomics technologies
Chairperson: Young-Ki Paik |
Session B (Theatre)
Protein Design and Engineering
Chairperson: R Manjunatha Kini |
10.30 am |
Speaker H11:
Laura
Beretta (Fred Hutchinson Cancer
Research Center, Seattle, USA)
Integrative
analysis of the liver proteome as a strategy for liver
disease biomarker discovery |
Speaker T11:
Andr?
M?ez (CEA, Saclay,
France)
Intrinsic
determinants of protein immunogenicity
|
11.00 am |
Speaker
H12:
Brian
Williamson (Applied
Biosystems, USA)
Cell
cycle proteomics in Caulobacter using a novel 8-plex set
of isobaric peptide labels |
Speaker
T12:
James
Tam (Nanyang
Technological University, Singapore
Quaternary
Protein Mimetics
|
11.30 am |
Speaker H13:
Newman
Sze (Nanyang
Technological University, Singapore)
Effective
top-down approach for proteome characterization
by
LTQ-Orbitrap: A step forward to elucidate
histone code |
Speaker T13:
Bob
Robinson (Institute of
Molecular and Cell Biology, Singapore)
The
structure of the WH2 motif |
12:00 noon |
Speaker H14:
Andrew
Wang (Academia
Sinica, Taipei)
Structural
and functional studies of enzyme targets for drug
discovery |
Speaker T14:
Song
Jianxing (NUS,
Singapore)
Assessing
Protein Folding and Design with the Pure Water
|
12.30-2:30 pm |
Lunch-Break
and Workshops (12:45- 2:15)
LT7A ?Thermo/Alpha Analytical
Ken Miller
Extending
the reach of proteomics with ETD: Improved protein
coverage, phosphopeptide detection and intact protein
analysis
LT7 ?/I> Invitrogen
Michael Synder,
PhD
Department of Molecular,
Cellular, & Developmental
Biology, Yale University,
New Haven, CT USA
Advancing Discovery with high density protein
microarrays - finding the markers that
matter.
Yoshiya
Oda (Eisai Co., Ltd. JAPAN)
Proteomic
technologies for drug discovery
Open to all
participants
|
Day 3 Afternoon
Sessions |
|
Session A (Hall)
Plant
Proteomics
Chairperson: Yu Hao |
Session B
(Theatre)
Structure-Function
Relationships
Chairperson: Ding Jeak
Ling |
2:30 pm |
Speaker H15:
Setsuko
Komatsu (National Institute
of Crop Science, Tsukuba, Japan)
Rice
proteomics: update and challenges on proteomics in rice |
Speaker T15:
Michael
James (University of
Alberta, Canada) The
NS5B polymerase from HCV: A target for drug design |
3:00 pm |
Speaker H16:
Ghasem Hosseini Salekdeh (Agricultural Biotechnology Research
Institute of Iran, Iran)
Proteomics
approach to uncover abiotic stress tolerance
mechanisms |
Speaker T16:
R
Manjunatha Kini (NUS,
Singapore)
Protein
scaffolds in snake venoms |
3:30 pm |
Oral presentation O5:
Brandon T.
Ruotolo (
University
of
Cambridge
,
Cambridge
,
UK
)
Ion
mobility-mass spectrometry analysis of large
protein-protein complexes
|
Oral presentation O6:
Mousumi Banerjee (Indian Institute of Science, Bangalore,
India)
Mutational
analysis of the role of residue 96 in modulating active
site loop conformation in Plasmodium falciparum Triosephosphate isomerase |
| 3.45
pm |
Poster Session and Exhibition / Refreshments (Foyer) |
| |
State-of-the-Art Lectures (Hall)
Chairperson: Bill
Jordan |
| 5:00 pm |
Speaker S5:
Caroline
Kampf (Royal Institute of
Technology, Stockholm, Sweden)
A
human protein atlas for normal and cancer tissues based on
micro array technologies
Sponsored by: Office of Life Sciences |
| 7:00 pm |
Conference Banquet (By invitation only) |
End
of Day 3
Top
Day 4 - Thursday, 7 December 2006 |
8:30 am |
Plenary P4: Glycoproteomics
Chi-Huey
Wong (The Scripps Research
Institute, USA)
New
Glycoproteomic Tools for Tackling the problem of
carbohydrate-mediated biological function
Sponsored by: BioRad
Chairperson: James
Tam |
9:30 am |
Exhibition
Viewing Period / Coffee Break (Foyer) |
Day 4 Morning
Sessions |
|
Session A (Hall)
Liver Proteomics
Chairperson: Jisnuson Svasti |
Session B (Theatre)
Structural Biology
II
Chairperson: Jayaraman
Sivaraman |
10.30 am |
Speaker H17:
Tadashi Kondo (National Cancer Center Research
Institute, Japan)
Toward
comprehensive expression proteomics for cancer
research |
Speaker T17:
Amit
Sharma (International Centre for
Genetic Engineering and Biotechnology, New Delhi,
India)
Elements
in malaria parasite Duffy binding-like domains necessary
for erythrocyte invasion |
11.00 am |
Speaker H18:
Fuchu
He (Beijing Institute of
Radiaion Medicine, Beijing, China)
Human
liver proteome project and its main progress
|
Speaker T18:
Julien
Lescar (Nanyang Technological
University, Singapore)
Towards
the design of antiviral compounds against dengue:
Crystallographic studies of the Dengue virus NS3 helicase
and the NS5 RNA-dependent RNA polymerase catalytic
domains |
11.30 am |
Speaker H19:
Maxey
Chung (NUS,
Singapore)
An
integrated proteomics approach for the discovery of
HBV-related HCC biomarkers |
Speaker T19:
Daiwen
Yang (NUS,
Singapore)
A
novel strategy for solution structure determination of
large proteins without deuteration |
12:00 noon |
Speaker H20:
Yasuhiro
Kuramitsu (Yamaguichi
University Graduate School of Medicine,
Japan)
Progress
in proteomic study of hepatocellular carcinoma with
hepatitis C virus infection for finding biomarkers and
therapeutic targets
|
Speaker T20:
Kim
Chu-Young (NUS,
Singapore)
Structural and mechanistic studies of a
modular polyketide synthase |
12.30-2.30 pm |
Lunch-Break
and Workshops (12:45- 2:15)
LT7A ?Agilent
Rudolf Grimm
Agilent’s
advanced solutions for front end proteomic sample
preparation and proteomics research
Chen Wei
OFFGEL Electrophoresis and LC-MS : A New
Multidimensional Approach to Mining of Low Abundant
Proteins in Complex Samples (cancelled)
LT7 ?Pall Life Sciences
Chitra
Thangavel
Depletion
of albumin and IgG from serum and plasma follwed by ion
exchange fractionation - rapid strategies for sample
complexity reduction for proteomics
Open to all
participants |
Day 4 Afternoon
Sessions |
|
Session A (Hall)
Clinical proteomics
Chairperson: Walter Blackstock |
Session B (Theatre)
Functional Genomics
Chairperson: Philippa Melamed |
2:30 pm |
Speaker H21:
Ravi
Sirdeshmukh (CCMB,
India)
Investigating
biomarkers for cancer and other clinical conditions in
Indian patients, using proteomics approaches
|
Speaker T21:
Adam
Yuan (NUS,
Singapore)
Insights
into siRNA loading into argonaute and RNA silencing
suppression by targeting argonaute |
3:00 pm |
Speaker H22:
Jisnuson
Svasti (Chulabhorn Research
Institute, Bangkok, Thailand)
Proteomic
studies of cholangiocarcinoma and hepatocellular cell
lines |
Speaker T22:
Ganesh Anand (NUS, Singapore)
Analysis
of protein interfaces by amide H/D exchange mass
spectrometry reveals parallels between cyclic nucleotide
and phosphorylation-dependent enzyme regulation |
3:30 pm |
Oral presentation O7:
Matthias
Pelzing (Bruker Daltonics,
Melbourne, Australia)
Characterisation
of intact proteins and antibodies by LC-and CZE-ESI-TOF
MS |
Oral
presentation O8:
Kang
Congbao (Nanyang
Technological University, Singapore)
Molecular
characterization of FK506 binding protein 35 from Plasmodium falciparum |
| 3.45
pm |
Poster Session and Exhibition / Refreshments (Foyer) |
|
State-of-the-Art Lectures
(Hall)
Chairperson: Susan Taylor |
4:30 pm |
Speaker S6:
Wah Chiu
(Baylor College of
Medicine, Houston Texas, USA)
Electron
cryo-microscopy of biological nano-machines
Sponsored by: Temasek Life Sciences
Laboratory
|
5:15 pm |
Speaker S7:
Erich
Wanker (Max Delbrueck Center for
Molecular Medicine, Berlin-Buch, Germany)
The
value of protein-protein interaction networks for systems
biology
Sponsored
by: Genome Institute
of Singapore |
6:00 pm |
Closing Ceremony and Poster Awards |
End
of Day 4 and the Conference
|
